While Katie Holmes' theatrical split from Tom Cruise made celeb hounds' jaws drop, her latest move is sure to spread grins across the Great White Way. The 33-year-old actress will return to Broadway this fall in Theresa Rebeck's "Dead Accounts," it was announced Thursday.

"I am thrilled to be coming back to the Broadway community and honored to be a part of this team," Holmes said in a statement.

Holmes made her Broadway debut in the 2008 revival of Arthur Miller's "All My Sons." On its opening night, about 35 protesters from the group Anonymous carried signs reading, "Run, Katie, Run" and chanting "Scientology kills."

The actress has revealed a number of projects in rapid succession since her split from Cruise (and the church of Scientology), from a guest appearance on "Project Runway" to "Molly," a film she co-wrote and is co-producing. "Dead Accounts," however, will be her first major role.

The play, which premiered at Cincinnati's Playhouse in the Park back in February, follows a Midwestern family, with the drama circling around the prodigal son Jack who unexpectedly returns home from New York to Cincinnati. Holmes will play his sister, Lorna, who has been caring for their parents.

Rebeck was a creator and executive producer of "Smash" ("was" being the operative word) and her latest play, "Seminar," starring Alan Rickman, was a Pulitzer Prize finalist.

"Dead Accounts" will open on Broadway at the Music Box Theatre. Other casting for the play has not yet been announced.